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In 1918, a flu pandemic claimed the lives of upward of 50 million people worldwide — including 30,000 New York City residents.

It’s with the centennial of that health crisis in mind that the Museum of the City of New York opens its newest exhibition.

“Germ City: Microbes and the Metropolis,” opening Friday, explores the threat of disease in a metropolis, including challenges, containment and care, from both a historical and contemporary context, with artifacts, scientific models and artwork on display.

The New York Academy of Medicine helped curate the exhibit and provided historical objects, such as an intubation kit for treating patients with diphtheria.

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